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 Table of Contents  
Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 22-23

Pyogenic granuloma: Adiagnostic dilemma

1 Department of Dermatology, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, India
2 Department of Pathology, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, India

Date of Web Publication14-Jun-2016

Correspondence Address:
Seema Rani
Department of Dermatology, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2349-6029.184002

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How to cite this article:
Rani S, Sharma P, Ahuja AK. Pyogenic granuloma: Adiagnostic dilemma. Indian J Dermatopathol Diagn Dermatol 2016;3:22-3

How to cite this URL:
Rani S, Sharma P, Ahuja AK. Pyogenic granuloma: Adiagnostic dilemma. Indian J Dermatopathol Diagn Dermatol [serial online] 2016 [cited 2022 May 26];3:22-3. Available from: https://www.ijdpdd.com/text.asp?2016/3/1/22/184002


Pyogenic granuloma also known as lobular capillary hemangioma is an acquired vascular hyperplasia of the skin and mucous membranes. It has been seen to develop following minor trauma, chronic irritation, viral infections and hormonal variations.[1],[2]

A 27-year-old woman presented with a 10 month history of an asymptomatic, thick, scaly lesion over the plantar aspect of left foot. It appeared during her third trimester of pregnancy. It was nonprogressive and not associated with bleeding. Physical examination revealed a well-defined, erythematous, hyperkeratotic partially blanchable, and a compressible plaque of size approximately 1 cm in diameter, covered with semi-adherent whitish coarse scales, present over plantar aspect of the left foot [Figure 1]. Dermoscopic examination revealed reddish homogeneous areas with white scales more marked at some places [Figure 2].
Figure 1: A single well-defined erythematous, hyperkeratotic plaque covered with scales present on the plantar surface of left foot

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Figure 2: Reddish homogeneous areas with white scales more marked at places. DP-MP17 filter eScope Pro (Optical, ×200)

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We kept the possibility of a vascular tumor and did an excisional biopsy. Histopathological examination revealed thickened stratum corneum and mild acanthosis. Dermis showed many capillary-sized vascular channels arranged in lobules along with mild chronic inflammatory infiltrate [Figure 3] and [Figure 4]. This confirmed the diagnosis of lobular capillary hemangioma.
Figure 3: Photomicrograph of skin biopsy showing hyperkeratosis, mild acanthosis, and flattening of rete ridges. Dermis shows lobular arrangement of thin walled capillary size vascular channels and mild chronic inflammatory infiltrate (H and E, ×40)

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Figure 4: Photomicrograph showing lobules composed of thin walled capillary size vascular channels, chronic inflammatory infiltrate, and mild edema (H and E, ×100)

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This case was an atypical clinical presentation of pyogenic granuloma present at an unusual site. It was difficult to reach the diagnosis on clinical presentation alone and the dermoscopic picture was also not very typical of pyogenic granuloma. The most frequently occurring dermoscopic features of pyogenic granuloma are presence of reddish homogeneous areas (92%), white collarette (85%), “white rail” lines that intersect the lesion (31%), and ulceration (46%).[3]

The typical clinical presentation of cutaneous pyogenic granuloma is a painless, red, crusted or ulcerated papule on the skin surface, developing over several months and finally stabilizing to form a fibrotic angioma, mostly located on head and neck (62.5%), trunk (19.7%), and limbs (17.9%).[1],[2] Oral mucosal nodules account for up to 70% of pyogenic granulomas in women.[2] Peak incidence is in the second decade of life, and they are often seen in children and young adults. Diagnosis of pyogenic granuloma is mostly made by history and clinical appearance, but in 38%, cases, clinical diagnosis proved to be wrong.[4] Misdiagnosis includes keratoacanthoma, inflamed seborrheic keratosis, melanocytic naevi, juvenile and malignant melanoma, warts, molluscum contagiosum, angioma, glomus tumor, eccrine poroma, Kaposi's sarcoma, and metastatic carcinoma.[5]

The pedunculated lesions are usually treated with cauterization or diathermy coagulation of the base, but recurrence rate is high after such treatment because the proliferating vessels at the base extend in a conical manner into the deeper dermis. According to the literature, the recurrence rate is 16% if we excise deep, with an ellipse of skin beneath the lesion and close the wound with sutures.[6] Other treatment modalities include imiquimod 5% cream, Nd:YAG laser, cryosurgery, intralesional steroids, flashlamp pulsed dye laser and injection of absolute ethanol.[5]

Our case had an atypical presentation in the form of a small erythematous plaque without any history of bleeding, despite being present over trauma-prone area. Although pyogenic granuloma can be diagnosed clinically, atypical presentations can lead to a diagnostic dilemma and should be further investigated by biopsy to reach a final diagnosis and to rule out other serious conditions. Till date, the patient has not shown any recurrence at the site of surgery.

Financial support and sponsorship

Department of Dermatology and Department of Pathology, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Conflicts of interest

There are no conflicts of interest.

  References Top

Patrice SJ, Wiss K, Mulliken JB. Pyogenic granuloma (lobular capillary hemangioma): A clinicopathologic study of 178 cases. Pediatr Dermatol 1991;8:267-76.  Back to cited text no. 1
Harris MN, Desai R, Chuang TY, Hood AF, Mirowski GW. Lobular capillary hemangiomas: An epidemiologic report, with emphasis on cutaneous lesions. J Am Acad Dermatol 2000;42:1012-6.  Back to cited text no. 2
Zaballos P, Llambrich A, Cuéllar F, Puig S, Malvehy J. Dermoscopic findings in pyogenic granuloma. Br J Dermatol 2006;154:1108-11.  Back to cited text no. 3
Rowe L. Granuloma pyogenicum: Differential diagnosis. AMA Arch Derm 1958;78:341-7.  Back to cited text no. 4
Calonje E. Soft tissue tumours and tumour-like condition. In: Burns DA, Breathnach SM, Cox NH, Griffiths CE, editors. Rook's Text Book of Dermatology. 8thed. London, UK: Blackwell Publishers; 2010. p.56.25-6.  Back to cited text no. 5
Taira JW, Hill TL, Everett MA. Lobular capillary hemangioma (pyogenic granuloma) with satellitosis. J Am Acad Dermatol 1992;27(2 Pt 2):297-300.  Back to cited text no. 6


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]

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